Pathophysiology of antiphospholipid antibodies.

نویسندگان

  • P G de Groot
  • R H W M Derksen
چکیده

The presence of antiphospholipid antibodies in plasma is a risk factor for thromboembolic complications. In vitro, however, the same antibodies can prolong dotting times in coagulation assays, a classic marker for a bleeding tendency. For years this contradiction has puzzled many scientists. Recently new insights into the interaction between antiphospholipid antibodies and their main target, the protein beta-2-glycoprotein I, have opened new avenues for the understanding of the pathology of this syndrome.

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عنوان ژورنال:
  • The Netherlands journal of medicine

دوره 62 8  شماره 

صفحات  -

تاریخ انتشار 2004